2 1942229Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI4Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others9Total19Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied at least 5,919 European ancestry cases, at least 130,691 European ancestry controls; replicated in 634,037 European ancestry cases, 1,308,690 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.022 lower (95% confidence interval 0.015-0.028); p = 3 × 10−14.
How common The C allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 18, band 18q21.2 — in an intron of TCF4.
What each result means
C/CTwo copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Depression. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
rs4801157 is a single position in the genome, in or near the TCF4 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4801157 linked to?
On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.
Does having rs4801157 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4801157 come from?
GWAS Catalog, Nature human behaviour 2021, PMID:33859377. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 1942229Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI4Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others9Total19Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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