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Asthma

ZPBP2 · rs4795397

Where this position leads

Condition: Asthma

What the study found

Who was studied 1,666 Puerto Rican child cases, 478 Puerto Rican adult cases, 1,505 Puerto Rican child controls, 1,388 Puerto Rican adult controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 4 × 10⁻¹².

How common The A allele had a frequency of about 64% in the people studied.

Where it sits Chromosome 17, band 17q21.1 — between genes, 0.7 kb from ZPBP2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Asthma compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Asthma.

G/G Published research associates this genotype with typical/baseline likelihood of Asthma — no copies of the reported risk allele.

Source

A meta-analysis of genome-wide association studies of asthma in Puerto Ricans

Yan Q, Brehm J, Pino-Yanes M, Forno E, Lin J, Oh SS, Acosta-Perez E, Laurie CC, Cloutier MM, Raby BA, Stilp AM, Sofer T

and 11 more — show all

Hu D, Huntsman S, Eng CS, Conomos MP, Rastogi D, Rice K, Canino G, Chen W, Barr RG, Burchard EG, Celedón JC

The European respiratory journal · 2017 · PMID 28461288

Questions about rs4795397

What is rs4795397?

rs4795397 is a single position in the genome, in or near the ZPBP2 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4795397 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs4795397 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4795397 come from?

GWAS Catalog, Eur Respir J 2017, PMID:28461288. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs4795397). MyGeneLog™. https://www.mygenelog.com/variants/rs4795397

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