Standard
Total cholesterol levels
near GRB7 · rs4795393
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,320,016 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0141 higher (95% confidence interval 0.011-0.017); p = 7 × 10−17.
How common The T allele had a frequency of about 63% in the people studied.
Where it sits Chromosome 17, band 17q12 — between genes, 0.3 kb from GRB7.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Total cholesterol levels — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total cholesterol levels.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total cholesterol levels compared to the general population.
Source
The power of genetic diversity in genome-wide association studies of lipids
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Nature · 2021 · PMID 34887591
Questions about rs4795393
What is rs4795393?
rs4795393 is a single position in the genome, in or near the near GRB7 gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4795393 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4795393 come from?
GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total cholesterol levels (rs4795393). MyGeneLog™. https://www.mygenelog.com/variants/rs4795393
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