Sensitive

Pancreatic cancer

HNF1B · rs4795218

Where this position leads

What the study found

Who was studied 9,040 European ancestry cases, 12,496 European ancestry controls; replicated in up to 2,737 cases, up to 4,752 controls.

The effect Each copy of the G allele carried 1.14 times the odds of Pancreatic cancer (95% confidence interval 1.09-1.19); p = 1 × 10⁻⁸.

How common The G allele had a frequency of about 77% in the people studied.

Where it sits Chromosome 17, band 17q12 — in an intron of HNF1B.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Pancreatic cancer — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pancreatic cancer.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pancreatic cancer compared to the general population.

Source

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Klein AP, Wolpin BM, Risch HA, Stolzenberg-Solomon RZ, Mocci E, Zhang M, Canzian F, Childs EJ, Hoskins JW, Jermusyk A, Zhong J, Chen F

and 112 more — show all

Albanes D, Andreotti G, Arslan AA, Babic A, Bamlet WR, Beane-Freeman L, Berndt SI, Blackford A, Borges M, Borgida A, Bracci PM, Brais L, Brennan P, Brenner H, Bueno-de-Mesquita B, Buring J, Campa D, Capurso G, Cavestro GM, Chaffee KG, Chung CC, Cleary S, Cotterchio M, Dijk F, Duell EJ, Foretova L, Fuchs C, Funel N, Gallinger S, M Gaziano JM, Gazouli M, Giles GG, Giovannucci E, Goggins M, Goodman GE, Goodman PJ, Hackert T, Haiman C, Hartge P, Hasan M, Hegyi P, Helzlsouer KJ, Herman J, Holcatova I, Holly EA, Hoover R, Hung RJ, Jacobs EJ, Jamroziak K, Janout V, Kaaks R, Khaw KT, Klein EA, Kogevinas M, Kooperberg C, Kulke MH, Kupcinskas J, Kurtz RJ, Laheru D, Landi S, Lawlor RT, Lee IM, LeMarchand L, Lu L, Malats N, Mambrini A, Mannisto S, Milne RL, Mohelníková-Duchoňová B, Neale RE, Neoptolemos JP, Oberg AL, Olson SH, Orlow I, Pasquali C, Patel AV, Peters U, Pezzilli R, Porta M, Real FX, Rothman N, Scelo G, Sesso HD, Severi G, Shu XO, Silverman D, Smith JP, Soucek P, Sund M, Talar-Wojnarowska R, Tavano F, Thornquist MD, Tobias GS, Van Den Eeden SK, Vashist Y, Visvanathan K, Vodicka P, Wactawski-Wende J, Wang Z, Wentzensen N, White E, Yu H, Yu K, Zeleniuch-Jacquotte A, Zheng W, Zheng W, Kraft P, Li D, Chanock S, Obazee O, Petersen GM, Amundadottir LT

Nature communications · 2018 · PMID 29422604 · open access

Questions about rs4795218

What is rs4795218?

rs4795218 is a single position in the genome, in or near the HNF1B gene. Published research associates it with pancreatic cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4795218 linked to?

On MyGeneLog this position is linked to Pancreatic Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs4795218 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4795218 come from?

GWAS Catalog, Nat Commun 2018, PMID:29422604. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pancreatic cancer (rs4795218). MyGeneLog™. https://www.mygenelog.com/variants/rs4795218

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