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Snoring

MAPT · rs4792897

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 359,916 European ancestry individuals.

The effect Each copy of the A allele carried 1.04 times the odds of Snoring (95% confidence interval 1.03-1.05); p = 3 × 10−8.

How common The A allele had a frequency of about 83% in the people studied.

Where it sits Chromosome 17, band 17q21.31 — in an intron of MAPT.

What each result means

A/A Two copies of the version the research linked to Snoring. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Snoring. That is a smaller link than two copies.
G/G No copy of the version the research linked to Snoring. This is the starting point the study compared everyone against.
Source

Questions about rs4792897

What is rs4792897?

rs4792897 is a single position in the genome, in or near the MAPT gene. Published research associates it with snoring. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4792897 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4792897 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Snoring (rs4792897). MyGeneLog™. https://www.mygenelog.com/variants/rs4792897

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