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Who was studied 6,956 European ancestry severe COVID-19 cases, 1,823 severe COVID-19 cases, 9,302 European ancestry SLE cases, 1,024,729 European ancestry controls, 328,311 controls.
The effect
Each copy of the G allele carried 0.90 times the odds of Severe COVID-19 or systemic lupus erythematosus (95% confidence interval 0.88-0.93); p = 7 × 10−10.
Where it sits Chromosome 17, band 17q21.31 — in a non-coding transcript of MAPT.
What each result means
G/GTwo copies of the version the research linked to Severe COVID-19 or systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Severe COVID-19 or systemic lupus erythematosus. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Severe COVID-19 or systemic lupus erythematosus. This is the starting point the study compared everyone against.
PLoS genetics · 2022 · PMID 36327221 · open access
Questions about rs4792891
What is rs4792891?
rs4792891 is a single position in the genome, in or near the MAPT gene. Published research associates it with severe covid-19 or systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4792891 linked to?
On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.
Does having rs4792891 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4792891 come from?
GWAS Catalog, PLoS genetics 2022, PMID:36327221. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Severe COVID-19 or systemic lupus erythematosus (rs4792891). MyGeneLog™. https://www.mygenelog.com/variants/rs4792891