A/APublished research associates this genotype with typical/baseline likelihood of Vitiligo — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2012, PMID:22561518)
A/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vitiligo. (GWAS Catalog, Nat Genet 2012, PMID:22561518)
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vitiligo compared to the general population. (GWAS Catalog, Nat Genet 2012, PMID:22561518)
Nature genetics · 2012 · PMID 22561518 · open access
Questions about rs4766578
What is rs4766578?
rs4766578 is a single position in the genome, in or near the SH2B3 gene. Published research associates it with vitiligo. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4766578 linked to?
On MyGeneLog this position is linked to Vitiligo. The research behind each link, and its sources, are set out on that condition page.
Does having rs4766578 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4766578 come from?
GWAS Catalog, Nat Genet 2012, PMID:22561518. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.