Standard

Gout

CUX2 · rs4766566

Where this position leads

Condition: Gout

rs4766566 Condition: Gout Gout Condition rs4766566 rs4766566 CUX2

What the study found

Who was studied 945 Japanese ancestry cases, 1,213 Japanese ancestry controls; replicated in 1,396 Japanese ancestry cases, 1,268 Japanese ancestry controls, 1,319 European ancestry cases, 514 European ancestry controls, 971 Polynesian ancestry cases, 565 Polynesian ancestry controls.

The effect Each copy of the T allele carried 1.51 times the odds of Gout (95% confidence interval 1.38-1.65); p = 4 × 10−20.

How common The T allele had a frequency of about 63% in the people studied.

Where it sits Chromosome 12, band 12q24.11 — in an intron of CUX2.

What each result means

C/C No copy of the version the research linked to Gout. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Gout. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Gout. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4766566

What is rs4766566?

rs4766566 is a single position in the genome, in or near the CUX2 gene. Published research associates it with gout. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4766566 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs4766566 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4766566 come from?

GWAS Catalog, Ann Rheum Dis 2016, PMID:27899376. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gout (rs4766566). MyGeneLog™. https://www.mygenelog.com/variants/rs4766566

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