Gene Knowledge Graph
UTC
Sensitive

Deep vein thrombosis [DVT] (PheCode 452.2)

VWF · rs4764533

Where this position leads

Condition: Venous Thromboembolism

rs4764533 Condition: Venous Thromboembolism Venous Thromboembolism Condition rs4764533 rs4764533 VWF

What the study found

Who was studied 4,478 African American or Afro-Caribbean cases, 115,423 African American or Afro-Caribbean controls, 14,636 European ancestry cases, 429,394 European ancestry controls, 1,241 Hispanic or Latin American cases, 57,995 Hispanic or Latin American controls.

The effect Each copy of the A allele shifted the measure 0.122 lower (95% confidence interval 0.094-0.151); p = 1 × 10−13.

How common The A allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 12, band 12p13.31 — in an intron of VWF.

What each result means

A/A Two copies of the version the research linked to Deep vein thrombosis [DVT] (PheCode 452.2). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Deep vein thrombosis [DVT] (PheCode 452.2). That is a smaller link than two copies.
G/G No copy of the version the research linked to Deep vein thrombosis [DVT] (PheCode 452.2). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs4764533

What is rs4764533?

rs4764533 is a single position in the genome, in or near the VWF gene. Published research associates it with deep vein thrombosis [dvt] (phecode 452.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4764533 linked to?

On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.

Does having rs4764533 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4764533 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Deep vein thrombosis [DVT] (PheCode 452.2) (rs4764533). MyGeneLog™. https://www.mygenelog.com/variants/rs4764533

← See all variants