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Who was studied 77,690 European ancestry cases, 1,167,040 European ancestry controls, 67,864 Japanese ancestry cases, 1,026,594 Japanese ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.0726 lower (95% confidence interval 0.06-0.086); p = 7 × 10−28.
How common The G allele had a frequency of about 70% in the people studied.
Where it sits Chromosome 11, band 11p15.1 — in an intron of NAV2.
What each result means
A/ANo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2023 · PMID 36653681 · open access
Questions about rs4757877
What is rs4757877?
rs4757877 is a single position in the genome, in or near the NAV2 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4757877 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs4757877 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4757877 come from?
GWAS Catalog, Nature genetics 2023, PMID:36653681. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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