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Longevity

HSD17B12 · rs4755737

Where this position leads

Condition: Human Lifespan and Longevity

rs4755737 Condition: Human Lifespan and Longevity Human Lifespan and Longevity Condition rs4755737 rs4755737 HSD17B12

What the study found

Who was studied up to 482,000 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0121 higher (95% confidence interval 0.0081-0.0161); p = 4 × 10−9.

Where it sits Chromosome 11, band 11p11.2 — in an intron of HSD17B12.

What each result means

A/A Two copies of the version the research linked to Longevity. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Longevity. That is a smaller link than two copies.
G/G No copy of the version the research linked to Longevity. This is the starting point the study compared everyone against.
Source

Questions about rs4755737

What is rs4755737?

rs4755737 is a single position in the genome, in or near the HSD17B12 gene. Published research associates it with longevity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4755737 linked to?

On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.

Does having rs4755737 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4755737 come from?

GWAS Catalog, G3 (Bethesda, Md.) 2019, PMID:31484785. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Longevity (rs4755737). MyGeneLog™. https://www.mygenelog.com/variants/rs4755737

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