Gene Knowledge Graph
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Height (baseline)

SPI1 · rs4752987

Where this position leads

Condition: Height

rs4752987 Condition: Height Height Condition rs4752987 rs4752987 SPI1

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−36, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 405,540 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0172 lower (95% confidence interval 0.014-0.02); p = 1 × 10−36.

How common The A allele had a frequency of about 32% in the people studied.

Where it sits Chromosome 11, band 11p11.2 — in an intron of SPI1.

What each result means

A/A Two copies of the version the research linked to Height (baseline). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Height (baseline). That is a smaller link than two copies.
G/G No copy of the version the research linked to Height (baseline). This is the starting point the study compared everyone against.
Source
Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline
Schoeler T, Pingault JB, Kutalik Z
Nature communications · 2025 · PMID 40374629 · open access

Questions about rs4752987

What is rs4752987?

rs4752987 is a single position in the genome, in or near the SPI1 gene. Published research associates it with height (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4752987 linked to?

On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.

Does having rs4752987 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4752987 come from?

GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Height (baseline) (rs4752987). MyGeneLog™. https://www.mygenelog.com/variants/rs4752987

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