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Cortical surface area

SHTN1 · rs4751614

What the study found

Who was studied 33,992 European ancestry individuals; replicated in 14,727 European ancestry individuals, 2,943 individuals.

The effect Each copy of the A allele shifted the measure 20.7 higher (95% confidence interval 15.06-26.43); p = 9 × 10−13.

How common The A allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 10, band 10q25.3 — in an intron of SHTN1.

What each result means

A/A Two copies of the version the research linked to Cortical surface area. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Cortical surface area. That is a smaller link than two copies.
T/T No copy of the version the research linked to Cortical surface area. This is the starting point the study compared everyone against.
Source

Questions about rs4751614

What is rs4751614?

rs4751614 is a single position in the genome, in or near the SHTN1 gene. Published research associates it with cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4751614 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4751614 come from?

GWAS Catalog, Science (New York, N.Y.) 2020, PMID:32193296. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cortical surface area (rs4751614). MyGeneLog™. https://www.mygenelog.com/variants/rs4751614

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