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Waist-hip ratio

SLC22A3 · rs474513

Where this position leads

Condition: Waist-to-Hip Ratio (Body Fat Distribution)

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁰, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 381,152 European female individuals.

The effect Each copy of the A allele shifted the measure 0.0116 higher (95% confidence interval 0.0081-0.0151); p = 7 × 10⁻¹¹.

How common The A allele had a frequency of about 51% in the people studied.

Where it sits Chromosome 6, band 6q25.3 — in an intron of SLC22A3.

What each result means

A/A Two copies of the version the research linked to Waist-hip ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Waist-hip ratio. That is a smaller link than two copies.

G/G No copy of the version the research linked to Waist-hip ratio. This is the starting point the study compared everyone against.

Source

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, Yang J, Jones S

and 10 more — show all

Beaumont R, Croteau-Chonka DC, Winkler TW, Hattersley AT, Loos RJF, Hirschhorn JN, Visscher PM, Frayling TM, Yaghootkar H, Lindgren CM

GIANT Consortium

Human molecular genetics · 2019 · PMID 30239722 · open access

Questions about rs474513

What is rs474513?

rs474513 is a single position in the genome, in or near the SLC22A3 gene. Published research associates it with waist-hip ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs474513 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.

Does having rs474513 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs474513 come from?

GWAS Catalog, Human molecular genetics 2019, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Waist-hip ratio (rs474513). MyGeneLog™. https://www.mygenelog.com/variants/rs474513

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