Sensitive

Bladder cancer

SMC2 · rs4743687

Where this position leads

What the study found

Who was studied 13,447 European ancestry cases, 342,580 European ancestry controls.

The effect Each copy of the C allele carried 1.10 times the odds of Bladder cancer (95% confidence interval 1.062-1.1329); p = 2 × 10⁻⁸.

How common The C allele had a frequency of about 44% in the people studied.

Where it sits Chromosome 9, band 9q31.1 — in the 5′ untranslated region of SMC2.

What each result means

C/C Two copies of the version the research linked to Bladder cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Bladder cancer. That is a smaller link than two copies.

T/T No copy of the version the research linked to Bladder cancer. This is the starting point the study compared everyone against.

Source

Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Koutros S, Kiemeney LA, Pal Choudhury P, Milne RL, Lopez de Maturana E, Ye Y, Joseph V, Florez-Vargas O, Dyrskjøt L, Figueroa J, Dutta D, Giles GG

and 88 more — show all

Hildebrandt MAT, Offit K, Kogevinas M, Weiderpass E, McCullough ML, Freedman ND, Albanes D, Kooperberg C, Cortessis VK, Karagas MR, Johnson A, Schwenn MR, Baris D, Furberg H, Bajorin DF, Cussenot O, Cancel-Tassin G, Benhamou S, Kraft P, Porru S, Carta A, Bishop T, Southey MC, Matullo G, Fletcher T, Kumar R, Taylor JA, Lamy P, Prip F, Kalisz M, Weinstein SJ, Hengstler JG, Selinski S, Harland M, Teo M, Kiltie AE, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Schned A, Lenz P, Riboli E, Brennan P, Tjønneland A, Otto T, Ovsiannikov D, Volkert F, Vermeulen SH, Aben KK, Galesloot TE, Turman C, De Vivo I, Giovannucci E, Hunter DJ, Hohensee C, Hunt R, Patel AV, Huang WY, Thorleifsson G, Gago-Dominguez M, Amiano P, Golka K, Stern MC, Yan W, Liu J, Li SA, Katta S, Hutchinson A, Hicks B, Wheeler WA, Purdue MP, McGlynn KA, Kitahara CM, Haiman CA, Greene MH, Rafnar T, Chatterjee N, Chanock SJ, Wu X, Real FX, Silverman DT, Garcia-Closas M, Stefansson K, Prokunina-Olsson L, Malats N, Rothman N

UROMOL Consortium

European urology · 2023 · PMID 37210288

Questions about rs4743687

What is rs4743687?

rs4743687 is a single position in the genome, in or near the SMC2 gene. Published research associates it with bladder cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4743687 linked to?

On MyGeneLog this position is linked to Bladder Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs4743687 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4743687 come from?

GWAS Catalog, European urology 2023, PMID:37210288. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bladder cancer (rs4743687). MyGeneLog™. https://www.mygenelog.com/variants/rs4743687

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