Standard
Tuberculosis
ASAP1 · rs4733781
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Tuberculosis compared to the general population. (GWAS Catalog, Nat Genet 2015, PMID:25774636)
A/C
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Tuberculosis. (GWAS Catalog, Nat Genet 2015, PMID:25774636)
C/C
Published research associates this genotype with typical/baseline likelihood of Tuberculosis — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2015, PMID:25774636)
Source
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration
Curtis J,
Luo Y,
Zenner HL,
Cuchet-Lourenço D,
Wu C,
Lo K,
Maes M,
Alisaac A,
Stebbings E,
Liu JZ,
Kopanitsa L,
Ignatyeva O
and 11 more — show all
Balabanova Y,
Nikolayevskyy V,
Baessmann I,
Thye T,
Meyer CG,
Nürnberg P,
Horstmann RD,
Drobniewski F,
Plagnol V,
Barrett JC,
Nejentsev S
Nature genetics · 2015 · PMID 25774636 · open access
Questions about rs4733781
What is rs4733781?
rs4733781 is a single position in the genome, in or near the ASAP1 gene. Published research associates it with tuberculosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4733781 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4733781 come from?
GWAS Catalog, Nat Genet 2015, PMID:25774636. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants