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Tuberculosis

ASAP1 · rs4733781

Where this position leads

Condition: Tuberculosis

rs4733781 Condition: Tuberculosis Tuberculosis Condition rs4733781 rs4733781 ASAP1

What the study found

Who was studied 5,530 European ancestry cases, 5,607 European ancestry controls; replicated in 1,085 Russian ancestry cases, 2,865 Russian ancestry controls, 2,277 Sub-Saharan African ancestry cases, 2,360 Sub-Saharan African ancestry controls.

The effect Each copy of the A allele carried 1.19 times the odds of Tuberculosis (95% confidence interval 1.14-1.25); p = 3 × 10−11.

How common The A allele had a frequency of about 69% in the people studied.

Where it sits Chromosome 8, band 8q24.21 — in an intron of ASAP1.

What each result means

A/A Two copies of the version the research linked to Tuberculosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Tuberculosis. That is a smaller link than two copies.
C/C No copy of the version the research linked to Tuberculosis. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4733781

What is rs4733781?

rs4733781 is a single position in the genome, in or near the ASAP1 gene. Published research associates it with tuberculosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4733781 linked to?

On MyGeneLog this position is linked to Tuberculosis. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs4733781?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4733781 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4733781 come from?

GWAS Catalog, Nat Genet 2015, PMID:25774636. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Tuberculosis (rs4733781). MyGeneLog™. https://www.mygenelog.com/variants/rs4733781

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