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Diffuse large B cell lymphoma

MYC · rs4733601

Where this position leads

Condition: Diffuse Large B Cell Lymphoma

What the study found

Who was studied 3,857 European ancestry cases, 7,666 European ancestry controls; replicated in 1,359 European ancestry cases, 4,557 European ancestry controls.

The effect Each copy of the A allele carried 1.19 times the odds of Diffuse large B cell lymphoma (95% confidence interval 1.12-1.25); p = 4 × 10⁻¹¹.

How common The A allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 8, band 8q24.21 — between genes, 36.4 kb from RN7SKP226.

What each result means

A/A Two copies of the version the research linked to Diffuse large B cell lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Diffuse large B cell lymphoma. That is a smaller link than two copies.

G/G No copy of the version the research linked to Diffuse large B cell lymphoma. This is the starting point the study compared everyone against.

Source

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Cerhan JR, Berndt SI, Vijai J, Ghesquières H, McKay J, Wang SS, Wang Z, Yeager M, Conde L, de Bakker PI, Nieters A, Cox D

and 110 more — show all

Burdett L, Monnereau A, Flowers CR, De Roos AJ, Brooks-Wilson AR, Lan Q, Severi G, Melbye M, Gu J, Jackson RD, Kane E, Teras LR, Purdue MP, Vajdic CM, Spinelli JJ, Giles GG, Albanes D, Kelly RS, Zucca M, Bertrand KA, Zeleniuch-Jacquotte A, Lawrence C, Hutchinson A, Zhi D, Habermann TM, Link BK, Novak AJ, Dogan A, Asmann YW, Liebow M, Thompson CA, Ansell SM, Witzig TE, Weiner GJ, Veron AS, Zelenika D, Tilly H, Haioun C, Molina TJ, Hjalgrim H, Glimelius B, Adami HO, Bracci PM, Riby J, Smith MT, Holly EA, Cozen W, Hartge P, Morton LM, Severson RK, Tinker LF, North KE, Becker N, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, Lightfoot T, Crouch S, Smith A, Roman E, Diver WR, Offit K, Zelenetz A, Klein RJ, Villano DJ, Zheng T, Zhang Y, Holford TR, Kricker A, Turner J, Southey MC, Clavel J, Virtamo J, Weinstein S, Riboli E, Vineis P, Kaaks R, Trichopoulos D, Vermeulen RC, Boeing H, Tjonneland A, Angelucci E, Di Lollo S, Rais M, Birmann BM, Laden F, Giovannucci E, Kraft P, Huang J, Ma B, Ye Y, Chiu BC, Sampson J, Liang L, Park JH, Chung CC, Weisenburger DD, Chatterjee N, Fraumeni JF Jr, Slager SL, Wu X, de Sanjose S, Smedby KE, Salles G, Skibola CF, Rothman N, Chanock SJ

Nature genetics · 2014 · PMID 25261932 · open access

Questions about rs4733601

What is rs4733601?

rs4733601 is a single position in the genome, in or near the MYC gene. Published research associates it with diffuse large b cell lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4733601 linked to?

On MyGeneLog this position is linked to Diffuse Large B Cell Lymphoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs4733601 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4733601 come from?

GWAS Catalog, Nat Genet 2014, PMID:25261932. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Diffuse large B cell lymphoma (rs4733601). MyGeneLog™. https://www.mygenelog.com/variants/rs4733601

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