NRG1 · rs4733129
Where this position leads
Condition: Thyroid Cancer
What the study found
Who was studied 6,056 European ancestry cases, 907,977 European ancestry controls, 4,661 East Asian ancestry cases, 354,129 East Asian ancestry controls, 5,450 African, Admixed American, European, East Asian, South Asian or unknown ancestry cases, 1,168,268 African, Admixed American, European, East Asian, South Asian or unknown ancestry controls.
The effect Each copy of the T allele shifted the measure 0.255 lower (95% confidence interval 0.23-0.28); p = 4 × 10−100.
Where it sits Chromosome 8, band 8p12 — in an intron of NRG1.
2026-07-10 · Jee YH, et al. Nature Communications 2026, PMID:42431967
Genetic drivers of etiologic heterogeneity in thyroid cancer
Newly curated by the GWAS Catalog: 66 associations across 1 trait ("Thyroid cancer"), from Jee YH, et al. in Nature Communications, 2026. The catalogue records its sample as 10,717 cases and 1,262,106 controls. This site already has 22 of its 66 positions — 13 on the Thyroid Cancer page; 2 on the Ovarian Cancer page; 2 on the Blood Cell Counts page — including rs4733129 (NRG1), rs116909374 (MBIP), rs10069690 (TERT). Everything above is from the catalogue's records, assembled by code; the paper itself is linked. PMID:42431967.
rs4733129 is a single position in the genome, in or near the NRG1 gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2026, PMID:42431967. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thyroid cancer (rs4733129). MyGeneLog™. https://www.mygenelog.com/variants/rs4733129