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Vertex-wise cortical surface area

near HGF · rs4732409

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 33,748 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 6.4 z score higher; p = 2 × 10⁻¹⁰.

How common The A allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 7, band 7q21.11 — between genes, 38.1 kb from HGF.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vertex-wise cortical surface area compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vertex-wise cortical surface area.

G/G Published research associates this genotype with typical/baseline likelihood of Vertex-wise cortical surface area — no copies of the reported risk allele.

Source

The genetic architecture of human cortical folding

van der Meer D, Kaufmann T, Shadrin AA, Makowski C, Frei O, Roelfs D, Monereo-Sánchez J, Linden DEJ, Rokicki J, Alnæs D, de Leeuw C, Thompson WK

and 5 more — show all

Loughnan R, Fan CC, Westlye LT, Andreassen OA, Dale AM

Science advances · 2021 · PMID 34910505 · open access

Questions about rs4732409

What is rs4732409?

rs4732409 is a single position in the genome, in or near the near HGF gene. Published research associates it with vertex-wise cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4732409 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4732409 come from?

GWAS Catalog, Science advances 2021, PMID:34910505. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Vertex-wise cortical surface area (rs4732409). MyGeneLog™. https://www.mygenelog.com/variants/rs4732409

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