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Psoriasis

near IRF5 · rs4728141

Where this position leads

Condition: Psoriasis

rs4728141 Condition: Psoriasis Psoriasis Condition rs4728141 rs4728141 near IRF5

What the study found

Who was studied 36,466 European ancestry cases, 458,078 European ancestry controls.

The effect Each copy of the T allele carried 0.94 times the odds of Psoriasis (95% confidence interval 0.92-0.95); p = 1 × 10−12.

Where it sits Chromosome 7, band 7q32.1 — between genes, 6.5 kb from IRF5.

What each result means

C/C No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S, Assmann G, Baudry D
and 73 more — show all
Behrens F, Billi AC, Brown MA, Burkhardt H, Capon F, Chung R, Curtis CJ, Duckworth M, Ellinghaus E, FitzGerald O, Gerdes S, Griffiths CEM, Gulliver S, Helliwell PS, Ho P, Hoffmann P, Holmen OL, Huang ZM, Hveem K, Jadon D, Köhm M, Kraus C, Lamacchia C, Lee SH, Ma F, Mahil SK, McHugh N, McManus R, Modalsli EH, Nissen MJ, Nöthen M, Oji V, Oksenberg JR, Patrick MT, Perez White BE, Ramming A, Rech J, Rosen C, Sarkar MK, Schett G, Schmidt B, Tejasvi T, Traupe H, Voorhees JJ, Wacker EM, Warren RB, Wasikowski R, Weidinger S, Wen X, Zhang Z, Barton A, Chandran V, Esko T, Foerster J, Franke A, Gladman DD, Gudjonsson JE, Gulliver W, Hüffmeier U, Kingo K, Kõks S, Liao W, Løset M, Mägi R, Nair RP, Rahman P, Reis A, Smith CH, Di Meglio P, Barker JN, Tsoi LC, Simpson MA, Elder JT
BSTOP study group · Estonian Biobank research team
Nature communications · 2025 · PMID 40021644 · open access

Questions about rs4728141

What is rs4728141?

rs4728141 is a single position in the genome, in or near the near IRF5 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4728141 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs4728141 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4728141 come from?

GWAS Catalog, Nature communications 2025, PMID:40021644. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs4728141). MyGeneLog™. https://www.mygenelog.com/variants/rs4728141

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