Gene Knowledge Graph
UTC
Sensitive

Peripheral artery disease

IL6 · rs4722172

Where this position leads

Condition: Peripheral Artery Disease

rs4722172 Condition: Peripheral Artery Disease Peripheral Artery Disease Condition rs4722172 rs4722172 IL6

What the study found

Who was studied 24,009 European ancestry cases, 150,983 European ancestry controls, 5,373 African ancestry cases, 42,485 African ancestry controls, 1,925 Hispanic cases, 18,285 Hispanic controls; replicated in 5,117 European ancestry cases, 389,291 European ancestry controls.

The effect Each copy of the G allele carried 1.08 times the odds of Peripheral artery disease (95% confidence interval 1.05-1.10); p = 4 × 10−11.

How common The G allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 7, band 7p15.3 — between genes, 0.8 kb from MTCYBP42.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Peripheral artery disease — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Peripheral artery disease.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Peripheral artery disease compared to the general population.
Source
Genome-wide association study of peripheral artery disease in the Million Veteran Program
Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Natarajan P, Arya S, Small A
and 24 more — show all
Sun YV, Vujkovic M, Freiberg MS, Wang L, Chen J, Saleheen D, Lee JS, Miller DR, Reaven P, Alba PR, Patterson OV, DuVall SL, Boden WE, Beckman JA, Gaziano JM, Concato J, Rader DJ, Cho K, Chang KM, Wilson PWF, O'Donnell CJ, Kathiresan S, Tsao PS, Damrauer SM
VA Million Veteran Program
Nature medicine · 2019 · PMID 31285632 · open access

Questions about rs4722172

What is rs4722172?

rs4722172 is a single position in the genome, in or near the IL6 gene. Published research associates it with peripheral artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4722172 linked to?

On MyGeneLog this position is linked to Peripheral Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs4722172 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4722172 come from?

GWAS Catalog, Nature medicine 2019, PMID:31285632. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Peripheral artery disease (rs4722172). MyGeneLog™. https://www.mygenelog.com/variants/rs4722172

← See all variants