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Who was studied 575,531 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.018 lower (95% confidence interval 0.014-0.022); p = 6 × 10−17.
Where it sits Chromosome 6, band 6p21.1 — in an intron of TFEB.
What each result means
A/ATwo copies of the version the research linked to C-reactive protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to C-reactive protein levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to C-reactive protein levels. This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 35459240 · open access
Questions about rs4714508
What is rs4714508?
rs4714508 is a single position in the genome, in or near the TFEB gene. Published research associates it with c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4714508 linked to?
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs4714508 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4714508 come from?
GWAS Catalog, Nature communications 2022, PMID:35459240. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
C-reactive protein levels (rs4714508). MyGeneLog™. https://www.mygenelog.com/variants/rs4714508