Standard

Bioavailable testosterone levels

SLC17A3 · rs4712976

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹¹, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 188,507 European ancestry women.

The effect Each copy of the C allele shifted the measure 0.0186 higher (95% confidence interval 0.013-0.024); p = 3 × 10⁻¹¹.

How common The C allele had a frequency of about 73% in the people studied.

Where it sits Chromosome 6, band 6p22.2 — in an intron of SLC17A3.

What each result means

C/C Two copies of the version the research linked to Bioavailable testosterone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Bioavailable testosterone levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to Bioavailable testosterone levels. This is the starting point the study compared everyone against.

Source

Using human genetics to understand the disease impacts of testosterone in men and women

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, Erzurumluoglu AM, Hollis B

and 10 more — show all

O'Mara TA, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB

Endometrial Cancer Association Consortium

Nature medicine · 2020 · PMID 32042192 · open access

Questions about rs4712976

What is rs4712976?

rs4712976 is a single position in the genome, in or near the SLC17A3 gene. Published research associates it with bioavailable testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4712976 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4712976 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Bioavailable testosterone levels (rs4712976). MyGeneLog™. https://www.mygenelog.com/variants/rs4712976

← See all variants