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Who was studied 2,495 East Asian ancestry cases, 4,283 East Asian ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.247 lower (95% confidence interval 0.17-0.32); p = 2 × 10−10.
Where it sits Chromosome 6, band 6q27 — between genes, 3.6 kb from CCR6.
What each result means
C/CNo copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of hepatology · 2021 · PMID 34033851 · open access
Questions about rs4709148
What is rs4709148?
rs4709148 is a single position in the genome, in or near the near CCR6 gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4709148 linked to?
On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs4709148 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4709148 come from?
GWAS Catalog, Journal of hepatology 2021, PMID:34033851. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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