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Who was studied 14,988 European ancestry individuals with no NVP, 14,292 European ancestry individuals with slight NVP, 17,786 European individuals with moderate NVP, 5,445 European ancestry individuals with severe NVP, 1,220 European ancestry individuals with very severe NVP.
The effect
Each copy of the C allele shifted the measure 0.043 higher (95% confidence interval 0.03-0.056); p = 3 × 10−10.
How common The C allele had a frequency of about 43% in the people studied.
Where it sits Chromosome 6, band 6q15 — in an intron of CASC6.
What each result means
C/CTwo copies of the version the research linked to Severity of nausea and vomiting of pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Severity of nausea and vomiting of pregnancy. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Severity of nausea and vomiting of pregnancy. This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 29563502 · open access
Questions about rs4707680
What is rs4707680?
rs4707680 is a single position in the genome, in or near the MAP3K7 gene. Published research associates it with severity of nausea and vomiting of pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4707680 linked to?
On MyGeneLog this position is linked to Nausea and Vomiting of Pregnancy (Hyperemesis Gravidarum). The research behind each link, and its sources, are set out on that condition page.
Does having rs4707680 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4707680 come from?
GWAS Catalog, Nat Commun 2018, PMID:29563502. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 2521912316Reads by AI crawlersClaude0ChatGPT2Google · Gemini1Perplexity0Meta AI9Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others6Total25Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Severity of nausea and vomiting of pregnancy (rs4707680). MyGeneLog™. https://www.mygenelog.com/variants/rs4707680