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C-reactive protein levels

IRF1 · rs4705952

Where this position leads

What the study found

Who was studied 63,678 European ancestry individuals 1,792 Erasmus Rucphen individuals, 715 Orcadian individuals; replicated in 16,540 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.042 higher (95% confidence interval 0.03-0.05); p = 1 × 10⁻⁸.

Where it sits Chromosome 5, band 5q31.1 — in an intron of IRF1.

What each result means

A/A No copy of the version the research linked to C-reactive protein levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to C-reactive protein levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to C-reactive protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, Baumert J, Strachan DP

and 102 more — show all

Fuchsberger C, Vitart V, Wilson JF, Paré G, Naitza S, Rudock ME, Surakka I, de Geus EJ, Alizadeh BZ, Guralnik J, Shuldiner A, Tanaka T, Zee RY, Schnabel RB, Nambi V, Kavousi M, Ripatti S, Nauck M, Smith NL, Smith AV, Sundvall J, Scheet P, Liu Y, Ruokonen A, Rose LM, Larson MG, Hoogeveen RC, Freimer NB, Teumer A, Tracy RP, Launer LJ, Buring JE, Yamamoto JF, Folsom AR, Sijbrands EJ, Pankow J, Elliott P, Keaney JF, Sun W, Sarin AP, Fontes JD, Badola S, Astor BC, Hofman A, Pouta A, Werdan K, Greiser KH, Kuss O, Meyer zu Schwabedissen HE, Thiery J, Jamshidi Y, Nolte IM, Soranzo N, Spector TD, Völzke H, Parker AN, Aspelund T, Bates D, Young L, Tsui K, Siscovick DS, Guo X, Rotter JI, Uda M, Schlessinger D, Rudan I, Hicks AA, Penninx BW, Thorand B, Gieger C, Coresh J, Willemsen G, Harris TB, Uitterlinden AG, Järvelin MR, Rice K, Radke D, Salomaa V, Willems van Dijk K, Boerwinkle E, Vasan RS, Ferrucci L, Gibson QD, Bandinelli S, Snieder H, Boomsma DI, Xiao X, Campbell H, Hayward C, Pramstaller PP, van Duijn CM, Peltonen L, Psaty BM, Gudnason V, Ridker PM, Homuth G, Koenig W, Ballantyne CM, Witteman JC, Benjamin EJ, Perola M, Chasman DI

Circulation · 2011 · PMID 21300955

Questions about rs4705952

What is rs4705952?

rs4705952 is a single position in the genome, in or near the IRF1 gene. Published research associates it with c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4705952 linked to?

On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs4705952 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4705952 come from?

GWAS Catalog, Circulation 2011, PMID:21300955. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

C-reactive protein levels (rs4705952). MyGeneLog™. https://www.mygenelog.com/variants/rs4705952

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