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Intracranial aneurysm

SLC22A5 · rs4705938

Where this position leads

Condition: Intracranial Aneurysm

rs4705938 Condition: Intracranial Aneurysm Intracranial Aneurysm Condition rs4705938 rs4705938 SLC22A5

What the study found

Who was studied 7,495 European ancestry cases, 71,934 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.12 higher (95% confidence interval 0.083-0.157); p = 3 × 10−10.

How common The T allele had a frequency of about 55% in the people studied.

Where it sits Chromosome 5, band 5q31.1 — in an intron of MIR3936HG.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Intracranial aneurysm — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intracranial aneurysm.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intracranial aneurysm compared to the general population.
Source
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, Terao C, Matsuda K
and 62 more — show all
Walters RG, Lin K, Li L, Millwood IY, Chen Z, Rouleau GA, Zhou S, Rannikmäe K, Sudlow CLM, Houlden H, van den Berg LH, Dina C, Naggara O, Gentric JC, Shotar E, Eugène F, Desal H, Winsvold BS, Børte S, Johnsen MB, Brumpton BM, Sandvei MS, Willer CJ, Hveem K, Zwart JA, Verschuren WMM, Friedrich CM, Hirsch S, Schilling S, Dauvillier J, Martin O, Jones GT, Bown MJ, Ko NU, Kim H, Coleman JRI, Breen G, Zaroff JG, Klijn CJM, Malik R, Dichgans M, Sargurupremraj M, Tatlisumak T, Amouyel P, Debette S, Rinkel GJE, Worrall BB, Pera J, Slowik A, Gaál-Paavola EI, Niemelä M, Jääskeläinen JE, von Und Zu Fraunberg M, Lindgren A, Broderick JP, Werring DJ, Woo D, Redon R, Bijlenga P, Kamatani Y, Veldink JH, Ruigrok YM
HUNT All-In Stroke · China Kadoorie Biobank Collaborative Group · BioBank Japan Project Consortium · ICAN Study Group · CADISP Group · Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators · International Stroke Genetics Consortium (ISGC)
Nature genetics · 2020 · PMID 33199917

Questions about rs4705938

What is rs4705938?

rs4705938 is a single position in the genome, in or near the SLC22A5 gene. Published research associates it with intracranial aneurysm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4705938 linked to?

On MyGeneLog this position is linked to Intracranial Aneurysm. The research behind each link, and its sources, are set out on that condition page.

Does having rs4705938 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4705938 come from?

GWAS Catalog, Nature genetics 2020, PMID:33199917. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Intracranial aneurysm (rs4705938). MyGeneLog™. https://www.mygenelog.com/variants/rs4705938

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