Gene Knowledge Graph
UTC
Standard

Migraine

HMGXB3 · rs4705403

Where this position leads

Condition: Migraine

rs4705403 Condition: Migraine Migraine Condition rs4705403 rs4705403 HMGXB3

What the study found

Who was studied 102,084 European ancestry cases, 771,257 European ancestry controls.

The effect Each copy of the A allele shifted the measure 1.05 higher (95% confidence interval 1.03-1.07); p = 1 × 10−8.

How common The A allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 5, band 5q32 — a missense change in HMGXB3.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Migraine compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Migraine.
G/G Published research associates this genotype with typical/baseline likelihood of Migraine — no copies of the reported risk allele.
Source
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA, Thomas LF, Noordam R, Benner C, Gormley P, Artto V, Banasik K
and 59 more — show all
Bjornsdottir A, Boomsma DI, Brumpton BM, Burgdorf KS, Buring JE, Chalmer MA, de Boer I, Dichgans M, Erikstrup C, Färkkilä M, Garbrielsen ME, Ghanbari M, Hagen K, Häppölä P, Hottenga JJ, Hrafnsdottir MG, Hveem K, Johnsen MB, Kähönen M, Kristoffersen ES, Kurth T, Lehtimäki T, Lighart L, Magnusson SH, Malik R, Pedersen OB, Pelzer N, Penninx BWJH, Ran C, Ridker PM, Rosendaal FR, Sigurdardottir GR, Skogholt AH, Sveinsson OA, Thorgeirsson TE, Ullum H, Vijfhuizen LS, Widén E, van Dijk KW, Aromaa A, Belin AC, Freilinger T, Ikram MA, Järvelin MR, Raitakari OT, Terwindt GM, Kallela M, Wessman M, Olesen J, Chasman DI, Nyholt DR, Stefánsson H, Stefansson K, van den Maagdenberg AMJM, Hansen TF, Ripatti S, Zwart JA, Palotie A, Pirinen M
International Headache Genetics Consortium · HUNT All-in Headache · Danish Blood Donor Study Genomic Cohort
Nature genetics · 2022 · PMID 35115687 · open access

Questions about rs4705403

What is rs4705403?

rs4705403 is a single position in the genome, in or near the HMGXB3 gene. Published research associates it with migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4705403 linked to?

On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.

Does having rs4705403 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4705403 come from?

GWAS Catalog, Nature genetics 2022, PMID:35115687. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Migraine (rs4705403). MyGeneLog™. https://www.mygenelog.com/variants/rs4705403

← See all variants