Standard

Height

ADAMTS3 · rs4694123

Where this position leads

Condition: Height

rs4694123 Condition: Height Height Condition rs4694123 rs4694123 ADAMTS3

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−27, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.011 higher (95% confidence interval 0.009-0.013); p = 2 × 10−27.

How common The C allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 4, band 4q13.3 — in an intron of ADAMTS3.

What each result means

C/C Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Height. That is a smaller link than two copies.
T/T No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
Source

Questions about rs4694123

What is rs4694123?

rs4694123 is a single position in the genome, in or near the ADAMTS3 gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4694123 linked to?

On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.

Does having rs4694123 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4694123 come from?

GWAS Catalog, Nature 2022, PMID:36224396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Height (rs4694123). MyGeneLog™. https://www.mygenelog.com/variants/rs4694123

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