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Sensitive

Type 2 diabetes

WFS1 · rs4689388

Where this position leads

Condition: Type 2 Diabetes

rs4689388 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs4689388 rs4689388 WFS1

What the study found

Who was studied 6,353 South Asian ancestry cases, 7,179 South Asian ancestry controls, 3,871 European ancestry cases, 16,427 European ancestry controls, 34,840 cases, 114,981 controls; replicated in 7,888 South Asian ancestry cases, 20,679 South Asian ancestry controls, 387 European ancestry cases, 2,092 European ancestry controls, 19,998 East Asian ancestry cases, 30,983 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0835 higher (95% confidence interval 0.063-0.104); p = 8 × 10−15.

How common The A allele had a frequency of about 62% in the people studied.

Where it sits Chromosome 4, band 4p16.1 — between genes, 1.5 kb from WFS1.

What each result means

A/A Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
G/G No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Source
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Zhao W, Rasheed A, Tikkanen E, Lee JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander M, Damrauer S, Small A, Asma S
and 78 more — show all
Imamura M, Yamauch T, Chambers JC, Chen P, Sapkota BR, Shah N, Jabeen S, Surendran P, Lu Y, Zhang W, Imran A, Abbas S, Majeed F, Trindade K, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Mehmood K, Ahmed N, Qureshi IH, Tanveer-Us-Salam, Iqbal W, Malik U, Mehra N, Kuo JZ, Sheu WH, Guo X, Hsiung CA, Juang JJ, Taylor KD, Hung YJ, Lee WJ, Quertermous T, Lee IT, Hsu CC, Bottinger EP, Ralhan S, Teo YY, Wang TD, Alam DS, Di Angelantonio E, Epstein S, Nielsen SF, Nordestgaard BG, Tybjaerg-Hansen A, Young R, Benn M, Frikke-Schmidt R, Kamstrup PR, Jukema JW, Sattar N, Smit R, Chung RH, Liang KW, Anand S, Sanghera DK, Ripatti S, Loos RJF, Kooner JS, Tai ES, Rotter JI, Chen YI, Frossard P, Maeda S, Kadowaki T, Reilly M, Pare G, Melander O, Salomaa V, Rader DJ, Danesh J, Voight BF, Saleheen D
CHD Exome+ Consortium · EPIC-CVD Consortium · EPIC-Interact Consortium · Michigan Biobank
Nature genetics · 2017 · PMID 28869590 · open access

Questions about rs4689388

What is rs4689388?

rs4689388 is a single position in the genome, in or near the WFS1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4689388 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs4689388 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4689388 come from?

GWAS Catalog, Nat Genet 2017, PMID:28869590. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs4689388). MyGeneLog™. https://www.mygenelog.com/variants/rs4689388

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