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Who was studied 58,783 European ancestry cases, 633,203 European ancestry controls.
The effect
Each copy of the A allele carried 1.12 times the odds of Hypothyroidism (95% confidence interval 1.1-1.13); p = 1 × 10−41.
Where it sits Chromosome 3, band 3q28 — in an intron of LPP.
What each result means
A/ATwo copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
European journal of endocrinology · 2024 · PMID 39067062
Questions about rs4686955
What is rs4686955?
rs4686955 is a single position in the genome, in or near the LPP gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4686955 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs4686955 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4686955 come from?
GWAS Catalog, European journal of endocrinology 2024, PMID:39067062. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1512129Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple1China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others9Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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