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Cerebrospinal fluid p-tau levels in APOE e4 non-carriers

near GMNC · rs4686570

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,141 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 7.01 z score higher; p = 2 × 10⁻¹².

How common The A allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 3, band 3q28 — between genes, 57.8 kb from GMNC.

What each result means

A/A Two copies of the version the research linked to Cerebrospinal fluid p-tau levels in APOE e4 non-carriers. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Cerebrospinal fluid p-tau levels in APOE e4 non-carriers. That is a smaller link than two copies.

G/G No copy of the version the research linked to Cerebrospinal fluid p-tau levels in APOE e4 non-carriers. This is the starting point the study compared everyone against.

Source

Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

Jansen IE, van der Lee SJ, Gomez-Fonseca D, de Rojas I, Dalmasso MC, Grenier-Boley B, Zettergren A, Mishra A, Ali M, Andrade V, Bellenguez C, Kleineidam L

and 134 more — show all

Küçükali F, Sung YJ, Tesí N, Vromen EM, Wightman DP, Alcolea D, Alegret M, Alvarez I, Amouyel P, Athanasiu L, Bahrami S, Bailly H, Belbin O, Bergh S, Bertram L, Biessels GJ, Blennow K, Blesa R, Boada M, Boland A, Buerger K, Carracedo Á, Cervera-Carles L, Chene G, Claassen JAHR, Debette S, Deleuze JF, de Deyn PP, Diehl-Schmid J, Djurovic S, Dols-Icardo O, Dufouil C, Duron E, Düzel E, Fladby T, Fortea J, Frölich L, García-González P, Garcia-Martinez M, Giegling I, Goldhardt O, Gobom J, Grimmer T, Haapasalo A, Hampel H, Hanon O, Hausner L, Heilmann-Heimbach S, Helisalmi S, Heneka MT, Hernández I, Herukka SK, Holstege H, Jarholm J, Kern S, Knapskog AB, Koivisto AM, Kornhuber J, Kuulasmaa T, Lage C, Laske C, Leinonen V, Lewczuk P, Lleó A, de Munain AL, Lopez-Garcia S, Maier W, Marquié M, Mol MO, Montrreal L, Moreno F, Moreno-Grau S, Nicolas G, Nöthen MM, Orellana A, Pålhaugen L, Papma JM, Pasquier F, Perneczky R, Peters O, Pijnenburg YAL, Popp J, Posthuma D, Pozueta A, Priller J, Puerta R, Quintela I, Ramakers I, Rodriguez-Rodriguez E, Rujescu D, Saltvedt I, Sanchez-Juan P, Scheltens P, Scherbaum N, Schmid M, Schneider A, Selbæk G, Selnes P, Shadrin A, Skoog I, Soininen H, Tárraga L, Teipel S, Tijms B, Tsolaki M, Van Broeckhoven C, Van Dongen J, van Swieten JC, Vandenberghe R, Vidal JS, Visser PJ, Vogelgsang J, Waern M, Wagner M, Wiltfang J, Wittens MMJ, Zetterberg H, Zulaica M, van Duijn CM, Bjerke M, Engelborghs S, Jessen F, Teunissen CE, Pastor P, Hiltunen M, Ingelsson M, Andreassen OA, Clarimón J, Sleegers K, Ruiz A, Ramirez A, Cruchaga C, Lambert JC, van der Flier W

EADB consortium · GR@ACE study group

Acta neuropathologica · 2022 · PMID 36066633 · open access

Questions about rs4686570

What is rs4686570?

rs4686570 is a single position in the genome, in or near the near GMNC gene. Published research associates it with cerebrospinal fluid p-tau levels in apoe e4 non-carriers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4686570 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4686570 come from?

GWAS Catalog, Acta neuropathologica 2022, PMID:36066633. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cerebrospinal fluid p-tau levels in APOE e4 non-carriers (rs4686570). MyGeneLog™. https://www.mygenelog.com/variants/rs4686570

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