A/APublished research associates this genotype with typical/baseline likelihood of Psoriasis or type 2 diabetes (trans-disease meta-analysis) — no copies of the reported risk allele. (GWAS Catalog, J Invest Dermatol 2020, PMID:33385400)
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis or type 2 diabetes (trans-disease meta-analysis). (GWAS Catalog, J Invest Dermatol 2020, PMID:33385400)
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis or type 2 diabetes (trans-disease meta-analysis) compared to the general population. (GWAS Catalog, J Invest Dermatol 2020, PMID:33385400)
The Journal of investigative dermatology · 2021 · PMID 33385400
Questions about rs4686392
What is rs4686392?
rs4686392 is a single position in the genome, in or near the IGF2BP2 gene. Published research associates it with psoriasis or type 2 diabetes (trans-disease meta-analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4686392 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs4686392 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4686392 come from?
GWAS Catalog, J Invest Dermatol 2020, PMID:33385400. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.