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Who was studied 80,265 European and unknown ancestry cases, 305,011 European and unknown ancestry controls.
The effect
Each copy of the A allele carried 1.04 times the odds of Gastroesophageal reflux disease (95% confidence interval 1.0272-1.0516); p = 2 × 10−10.
Where it sits Chromosome 3, band 3p13 — between genes, 60 kb from RNU6-281P.
What each result means
A/ATwo copies of the version the research linked to Gastroesophageal reflux disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Gastroesophageal reflux disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Gastroesophageal reflux disease. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 31527586 · open access
Questions about rs4676893
What is rs4676893?
rs4676893 is a single position in the genome, in or near the FOXP1 gene. Published research associates it with gastroesophageal reflux disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4676893 linked to?
On MyGeneLog this position is linked to Gastroesophageal Reflux Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs4676893 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4676893 come from?
GWAS Catalog, Nature communications 2019, PMID:31527586. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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