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White blood cell count

near ITGA4 · rs4667283

Where this position leads

Conditions: Blood Cell Counts, Colon Polyp

rs4667283 Condition: Blood Cell Counts Blood Cell Counts Condition Condition: Colon Polyp Colon Polyp Condition rs4667283 rs4667283 near ITGA4

What the study found

Who was studied 350,470 European ancestry individuals, 154,355 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0272 higher (95% confidence interval 0.023-0.031); p = 1 × 10−42.

Where it sits Chromosome 2, band 2q31.3 — between genes, 8.7 kb from ITGA4.

What each result means

C/C No copy of the version the research linked to White blood cell count. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to White blood cell count. That is a smaller link than two copies.
T/T Two copies of the version the research linked to White blood cell count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4667283

What is rs4667283?

rs4667283 is a single position in the genome, in or near the near ITGA4 gene. Published research associates it with white blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4667283 linked to?

On MyGeneLog this position is linked to Blood Cell Counts, Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs4667283 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4667283 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

White blood cell count (rs4667283). MyGeneLog™. https://www.mygenelog.com/variants/rs4667283

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