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Psoriasis

REV3L · rs465969

Where this position leads

Condition: Psoriasis

rs465969 Condition: Psoriasis Psoriasis Condition rs465969 rs465969 REV3L

What the study found

Who was studied 4,212 European ancestry cases, 8,032 European ancestry controls.

The effect Each copy of the A allele carried 1.40 times the odds of Psoriasis (95% confidence interval 1.335-1.474); p = 8 × 10−12.

Where it sits Chromosome 6, band 6q21 — in an intron of REV3L.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
Baurecht H, Hotze M, Brand S, Büning C, Cormican P, Corvin A, Ellinghaus D, Ellinghaus E, Esparza-Gordillo J, Fölster-Holst R, Franke A, Gieger C
and 26 more — show all
Hubner N, Illig T, Irvine AD, Kabesch M, Lee YA, Lieb W, Marenholz I, McLean WH, Morris DW, Mrowietz U, Nair R, Nöthen MM, Novak N, O'Regan GM, Schreiber S, Smith C, Strauch K, Stuart PE, Trembath R, Tsoi LC, Weichenthal M, Barker J, Elder JT, Weidinger S, Cordell HJ, Brown SJ
Psoriasis Association Genetics Extension
American journal of human genetics · 2015 · PMID 25574825 · open access

Questions about rs465969

What is rs465969?

rs465969 is a single position in the genome, in or near the REV3L gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs465969 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs465969 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs465969 come from?

GWAS Catalog, Am J Hum Genet 2015, PMID:25574825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs465969). MyGeneLog™. https://www.mygenelog.com/variants/rs465969

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