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Psoriasis

REV3L · rs465969

Where this position leads

Condition: Psoriasis

rs465969 Condition: Psoriasis Psoriasis Condition rs465969 rs465969 REV3L

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis.
G/G Published research associates this genotype with typical/baseline likelihood of Psoriasis — no copies of the reported risk allele.
Source
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
Baurecht H, Hotze M, Brand S, Büning C, Cormican P, Corvin A, Ellinghaus D, Ellinghaus E, Esparza-Gordillo J, Fölster-Holst R, Franke A, Gieger C
and 26 more — show all
Hubner N, Illig T, Irvine AD, Kabesch M, Lee YA, Lieb W, Marenholz I, McLean WH, Morris DW, Mrowietz U, Nair R, Nöthen MM, Novak N, O'Regan GM, Schreiber S, Smith C, Strauch K, Stuart PE, Trembath R, Tsoi LC, Weichenthal M, Barker J, Elder JT, Weidinger S, Cordell HJ, Brown SJ
Psoriasis Association Genetics Extension
American journal of human genetics · 2015 · PMID 25574825 · open access

Questions about rs465969

What is rs465969?

rs465969 is a single position in the genome, in or near the REV3L gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs465969 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs465969 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs465969 come from?

GWAS Catalog, Am J Hum Genet 2015, PMID:25574825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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