CHRM3 · rs4659554
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 372,869 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 5.49 higher; p = 4 × 10−8.
How common The A allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 1, band 1q43 — in the 3′ untranslated region of CHRM3-AS1.
rs4659554 is a single position in the genome, in or near the CHRM3 gene. Published research associates it with feeling worry. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Feeling worry (rs4659554). MyGeneLog™. https://www.mygenelog.com/variants/rs4659554