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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 336,066 British ancestry individuals.
The effect
Each copy of the G allele carried 1.05 times the odds of Smoking status (ever vs never smokers) (95% confidence interval 1.04-1.07); p = 8 × 10−15.
How common The G allele had a frequency of about 16% in the people studied.
Where it sits Chromosome 6, band 6q21 — in the 3′ untranslated region of REV3L.
What each result means
A/ANo copy of the version the research linked to Smoking status (ever vs never smokers). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Smoking status (ever vs never smokers). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Smoking status (ever vs never smokers). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs465646 is a single position in the genome, in or near the REV3L gene. Published research associates it with smoking status (ever vs never smokers). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs465646 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs465646 come from?
GWAS Catalog, Nature genetics 2020, PMID:32231276. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Smoking status (ever vs never smokers) (rs465646). MyGeneLog™. https://www.mygenelog.com/variants/rs465646