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C-reactive protein levels

near OR10J6P · rs4656241

Where this position leads

What the study found

Who was studied 575,531 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.088 lower (95% confidence interval 0.082-0.094); p = 3 × 10⁻²⁶⁴.

Where it sits Chromosome 1, band 1q23.2 — between genes, 45 kb from OR10J6P.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of C-reactive protein levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with C-reactive protein levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of C-reactive protein levels compared to the general population.

Source

Genetic analysis of over half a million people characterises C-reactive protein loci

Said S, Pazoki R, Karhunen V, Võsa U, Ligthart S, Bodinier B, Koskeridis F, Welsh P, Alizadeh BZ, Chasman DI, Sattar N, Chadeau-Hyam M

and 5 more — show all

Evangelou E, Jarvelin MR, Elliott P, Tzoulaki I, Dehghan A

Nature communications · 2022 · PMID 35459240 · open access

Questions about rs4656241

What is rs4656241?

rs4656241 is a single position in the genome, in or near the near OR10J6P gene. Published research associates it with c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4656241 linked to?

On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs4656241 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4656241 come from?

GWAS Catalog, Nature communications 2022, PMID:35459240. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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C-reactive protein levels (rs4656241). MyGeneLog™. https://www.mygenelog.com/variants/rs4656241

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