Sensitive

Ischemic stroke

LAMC1 · rs4652772

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied at least 26,047 African, African American ancestry individuals, at least 268,697 East Asian ancestry individuals, at least 1,479,471 European ancestry individuals, at least 15,080 Hispanic or Latin American individuals, at least 21,934 South Asian ancestry individuals; replicated in at least 22,495 European ancestry cases, at least 461,936 European ancestry controls, at least 8,368 African ancestry cases, at least 121,549 African ancestry controls, at least 1,983 Hispanic or Latin American cases, at least 49,053 Hispanic or Latin American controls, at least 217 Asian ancestry cases, at least 7,979 Asian ancestry controls.

The effect Each copy of the C allele carried 1.03 times the odds of Ischemic stroke (95% confidence interval 1.023-1.043); p = 4 × 10⁻¹¹.

Where it sits Chromosome 1, band 1q25.3 — in an intron of LAMC1.

What each result means

C/C Two copies of the version the research linked to Ischemic stroke. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Ischemic stroke. That is a smaller link than two copies.

G/G No copy of the version the research linked to Ischemic stroke. This is the starting point the study compared everyone against.

Source

Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries

Surakka I, Wu KH, Hornsby W, Wolford BN, Shen F, Zhou W, Huffman JE, Pandit A, Hu Y, Brumpton B, Skogholt AH, Gabrielsen ME

and 9 more — show all

Walters RG, Hveem K, Kooperberg C, Zöllner S, Wilson PWF, Sutton NR, Daly MJ, Neale BM, Willer CJ

TOPMed Stroke Working Group · Million Veteran Program (MVP) · Global Biobank Meta-analysis Initiative (GBMI)

Cell genomics · 2023 · PMID 37601974 · open access

Questions about rs4652772

What is rs4652772?

rs4652772 is a single position in the genome, in or near the LAMC1 gene. Published research associates it with ischemic stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4652772 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4652772 come from?

GWAS Catalog, Cell genomics 2023, PMID:37601974. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ischemic stroke (rs4652772). MyGeneLog™. https://www.mygenelog.com/variants/rs4652772

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