A/APublished research associates this genotype with typical/baseline likelihood of Multiple sclerosis — no copies of the reported risk allele. (GWAS Catalog, Nature 2011, PMID:21833088)
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Multiple sclerosis. (GWAS Catalog, Nature 2011, PMID:21833088)
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Multiple sclerosis compared to the general population. (GWAS Catalog, Nature 2011, PMID:21833088)
Source: GWAS Catalog, Nature 2011, PMID:21833088
Questions about rs4648356
What is rs4648356?
rs4648356 is a single position in the genome, in or near the MMEL1 gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4648356 linked to?
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs4648356 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4648356 come from?
GWAS Catalog, Nature 2011, PMID:21833088. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.