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Retinal dehydrogenase 2 levels

ALDH1A2 · rs4646605

What the study found

Who was studied 2,549 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.172 higher (95% confidence interval 0.12-0.23); p = 3 × 10−10.

How common The A allele had a frequency of about 43% in the people studied.

Where it sits Chromosome 15, band 15q21.3 — in an intron of ALDH1A2.

What each result means

A/A Two copies of the version the research linked to Retinal dehydrogenase 2 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Retinal dehydrogenase 2 levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to Retinal dehydrogenase 2 levels. This is the starting point the study compared everyone against.
Source

Questions about rs4646605

What is rs4646605?

rs4646605 is a single position in the genome, in or near the ALDH1A2 gene. Published research associates it with retinal dehydrogenase 2 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4646605 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4646605 come from?

GWAS Catalog, Nature genetics 2024, PMID:39528825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Retinal dehydrogenase 2 levels (rs4646605). MyGeneLog™. https://www.mygenelog.com/variants/rs4646605

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