Standard

Body mass index (UKB data field 21001)

near SLIT2 · rs4642249

What the study found

Who was studied 394,642 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.024 lower (95% confidence interval 0.018-0.03); p = 3 × 10−16.

How common The G allele had a frequency of about 89% in the people studied.

Where it sits Chromosome 4, band 4p15.31 — between genes, 164.5 kb from SLIT2.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Body mass index (UKB data field 21001) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index (UKB data field 21001).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index (UKB data field 21001) compared to the general population.
Source

Questions about rs4642249

What is rs4642249?

rs4642249 is a single position in the genome, in or near the near SLIT2 gene. Published research associates it with body mass index (ukb data field 21001). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4642249 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4642249 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (UKB data field 21001) (rs4642249). MyGeneLog™. https://www.mygenelog.com/variants/rs4642249

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