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Who was studied 3,504 European ancestry cases, 861,198 European ancestry controls.
The effect
Each copy of the T allele carried 1.28 times the odds of Otosclerosis (95% confidence interval 1.19-1.39); p = 7 × 10−11.
How common The T allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 16, band 16q12.2 — between genes, 12.5 kb from MTND5P34.
What each result means
C/CNo copy of the version the research linked to Otosclerosis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Otosclerosis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Otosclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 36653343 · open access
Questions about rs4636903
What is rs4636903?
rs4636903 is a single position in the genome, in or near the near MTND5P34 gene. Published research associates it with otosclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4636903 linked to?
On MyGeneLog this position is linked to Otosclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs4636903 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4636903 come from?
GWAS Catalog, Nature communications 2023, PMID:36653343. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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