COMT · rs4633
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 14,296 European ancestry individuals; replicated in 5,698 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.117 lower (95% confidence interval 0.097-0.137); p = 4 × 10−31.
How common The T allele had a frequency of about 52% in the people studied.
Where it sits Chromosome 22, band 22q11.21 — a synonymous change in COMT.
What ClinVar records
Classification
Benign for Tramadol response; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 8 submitters), last evaluated 2021-05-04.
ClinVar record 256785 NM_000754.4(COMT):c.186C>T (p.His62=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs4633 is a single position in the genome, in or near the COMT gene. Published research associates it with 3-methoxytyrosine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature medicine 2022, PMID:36357675. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
3-methoxytyrosine levels (rs4633). MyGeneLog™. https://www.mygenelog.com/variants/rs4633