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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 39,011 European ancestry individuals, 2,099 African ancestry individuals, 795 Hispanic individuals, 3,299 Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 7.24 Zscore lower; p = 1 × 10−14.
Where it sits Chromosome 10, band 10q24.33 — in an intron of SH3PXD2A.
What each result means
A/ATwo copies of the version the research linked to White matter hyperintensities. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to White matter hyperintensities. That is a smaller link than two copies.
G/GNo copy of the version the research linked to White matter hyperintensities. This is the starting point the study compared everyone against.
Nature communications · 2020 · PMID 32358547 · open access
Questions about rs4630220
What is rs4630220?
rs4630220 is a single position in the genome, in or near the SH3PXD2A gene. Published research associates it with white matter hyperintensities. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4630220 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4630220 come from?
GWAS Catalog, Nature communications 2020, PMID:32358547. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
White matter hyperintensities (rs4630220). MyGeneLog™. https://www.mygenelog.com/variants/rs4630220