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Early onset atrial fibrillation

HAND2 · rs4615152

Where this position leads

Condition: Atrial Fibrillation

rs4615152 Condition: Atrial Fibrillation Atrial Fibrillation Condition rs4615152 rs4615152 HAND2

What the study found

Who was studied 672 Korean ancestry cases, 3,700 Korean ancestry controls; replicated in 200 Korean ancestry cases, 1,812 Korean ancestry controls.

The effect Each copy of the C allele carried 1.51 times the odds of Early onset atrial fibrillation (95% confidence interval 1.35-1.68); p = 1 × 10−12.

How common The C allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 4, band 4q34.1 — inside HAND2-AS1.

What each result means

C/C Two copies of the version the research linked to Early onset atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Early onset atrial fibrillation. That is a smaller link than two copies.
T/T No copy of the version the research linked to Early onset atrial fibrillation. This is the starting point the study compared everyone against.
Source

Questions about rs4615152

What is rs4615152?

rs4615152 is a single position in the genome, in or near the HAND2 gene. Published research associates it with early onset atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4615152 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs4615152 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4615152 come from?

GWAS Catalog, Eur Heart J 2017, PMID:28460022. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Early onset atrial fibrillation (rs4615152). MyGeneLog™. https://www.mygenelog.com/variants/rs4615152

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