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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,237 Southern Han Chinese ancestry individuals; replicated in 4,093 East Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.5 lower; p = 9 × 10−10.
Where it sits Chromosome 8, band 8q24.23 — between genes, 111.3 kb from RNU6-144P.
What each result means
C/CTwo copies of the version the research linked to Spherical equivalent. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Spherical equivalent. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Spherical equivalent. This is the starting point the study compared everyone against.
NPJ genomic medicine · 2025 · PMID 40410244 · open access
Questions about rs4609227
What is rs4609227?
rs4609227 is a single position in the genome, in or near the near RNU6-144P gene. Published research associates it with spherical equivalent. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4609227 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4609227 come from?
GWAS Catalog, NPJ genomic medicine 2025, PMID:40410244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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