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Traumatic brain injury (TBI)

near TCF4 · rs4608411

What the study found

Who was studied 85,613 European ancestry cases, 164,172 European ancestry controls.

The effect Each copy of the T allele carried 1.04 times the odds of Traumatic brain injury (TBI) (95% confidence interval 1.03-1.05); p = 8 × 10−10.

How common The T allele had a frequency of about 32% in the people studied.

What each result means

C/C No copy of the version the research linked to Traumatic brain injury (TBI). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Traumatic brain injury (TBI). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Traumatic brain injury (TBI). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4608411

What is rs4608411?

rs4608411 is a single position in the genome, in or near the near TCF4 gene. Published research associates it with traumatic brain injury (tbi). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4608411 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4608411 come from?

GWAS Catalog, Molecular psychiatry 2024, PMID:37875548. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Traumatic brain injury (TBI) (rs4608411). MyGeneLog™. https://www.mygenelog.com/variants/rs4608411

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