1 1814229Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others9Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 9,851 European ancestry cases, 38,957 European ancestry controls; replicated in 10,257 European ancestry cases, 470,275 European ancestry controls.
The effect
Each copy of the A allele carried 1.13 times the odds of Restless legs syndrome (95% confidence interval 1.11-1.16); p = 3 × 10−27.
Where it sits Chromosome 1, band 1p21.1 — between genes, 152.5 kb from MTATP6P14.
What each result means
A/ATwo copies of the version the research linked to Restless legs syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Restless legs syndrome. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Restless legs syndrome. This is the starting point the study compared everyone against.
rs4603157 is a single position in the genome, in or near the near MTATP6P14 gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4603157 linked to?
On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs4603157 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4603157 come from?
GWAS Catalog, Annals of neurology 2024, PMID:39078117. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 1814229Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others9Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Restless legs syndrome (rs4603157). MyGeneLog™. https://www.mygenelog.com/variants/rs4603157